Adenovirus-Mediated Expression of -Adrenergic Receptor Kinase C-Terminus Reduces Intimal Hyperplasia and Luminal Stenosis of Arteriovenous Polytetrafluoroethylene Grafts in Pigs
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چکیده
Zhengyu Luo, Geoffrey Y. Akita, Taro Date, Christopher Treleaven, Karen A. Vincent, Denise Grafts in Pigs Intimal Hyperplasia and Luminal Stenosis of Arteriovenous Polytetrafluoroethylene -Adrenergic Receptor Kinase C-Terminus Reduces β Adenovirus-Mediated Expression of Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000160357.80517.92 2005;111:1679-1684; originally published online March 21, 2005; Circulation. http://circ.ahajournals.org/content/111/13/1679 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Adenovirus-mediated expression of beta-adrenergic receptor kinase C-terminus reduces intimal hyperplasia and luminal stenosis of arteriovenous polytetrafluoroethylene grafts in pigs.
BACKGROUND Hemodialysis vascular access dysfunction is the single most important cause of morbidity in kidney hemodialysis patients. Failure of an arteriovenous polytetrafluoroethylene (PTFE) graft, the most common form of hemodialysis access, is primarily due to intimal hyperplasia and thrombosis at the venous anastomosis. METHODS AND RESULTS This study was aimed at evaluating the efficacy a...
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T Objective: Approximately 50% of aortocoronary saphenous vein grafts are occluded 10 years after coronary revascularization surgery. Intimal hyperplasia, a critical component in saphenous vein graft failure, is defined by vascular smooth muscle cell proliferation, which is mediated in part by subunits of heterotrimeric G proteins (G ) and downstream effectors such as mitogen-activated protein ...
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Vein grafting results in the development of intimal hyperplasia with accompanying changes in guanine nucleotide–binding (G) protein expression and function. Several serum mitogens that act through G protein–coupled receptors, such as lysophosphatidic acid, stimulate proliferative pathways that are dependent on the G protein bg subunit (Gbg)–mediated activation of p21 . This study examines the r...
متن کاملG protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
Vein grafting results in the development of intimal hyperplasia with accompanying changes in guanine nucleotide-binding (G) protein expression and function. Several serum mitogens that act through G protein-coupled receptors, such as lysophosphatidic acid, stimulate proliferative pathways that are dependent on the G protein betagamma subunit (Gbetagamma)-mediated activation of p21ras. This stud...
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تاریخ انتشار 2005